The Effect of the Subcutaneous Injections of Suprarenal Cortical Extract ( Aqueous Solution ) on the Renal Excretion of Electrolytes in the Normal Dog

In earlier studies (1-3) we have observed that subcutaneous injections of suprarenal cortical extract affected the renal excretion of sodium, chloride and potassium in normal subjects and in normal dogs as well as in suprarenalectomized dogs and patients suffering from Addison's disease. With the isolation of steroid compounds from the suprarenal cortex (Kendall, and his coworkers, Reichstein, Wintersteiner and Pfiffner, and Grollman (4)) it has become possible to test crystalline preparations for their effect on the renal excretion of electrolytes and to determine whether this effect parallels theirpotency in maintaining suprarenalectomized animals. In addition to crystalline compounds ~ derived from the suprarenal cortex we have tested a synthetic compound (desoxy-corticosterone acetate) prepared by Steiger and Reichstein (5).